Estimation of platelet function inhibiting drugs on platelet adhesiveness

Platelet adhesiveness.

Platelet Adhesiveness

By MURRAY WEINER, M.D., KURT ZELTMACHER, M.D., CARL REICH, M.D., AND SHEPARD SHAPIRO, M.D. I N 1941, Helen Wright’ described a method for estimating the adhesive quality of platelets. Confirmation of the original findings by Spooner and Meyer’ established the procedure as a means of distinguishing this property of platelets. It is the purpose of the present report to evaluate the usefulness of ...

Platelet adhesiveness: the effect of centrifugation on the measurement of adhesiveness in platelet-rich plasma.

Platelet adhesiveness has been measured in citrated whole blood and in platelet-rich plasma obtained from normal subjects, splenectomized patients, and from patients in whom the diagnosis of recurrent venous thrombosis had been made. The duration of centrifugation used in the preparation of platelet-rich plasma was found to have a profound effect on the measurement of platelet adhesiveness beca...

Estimation of platelet adhesiveness on whole blood and platelet-rich plasma.

Platelet adhesive tests were carried out in parallel on whole blood and platelet-rich plasma. A column of glass microspherules was used and adenosine diphosphate (ADP) was added to the platelet-rich plasma before passage through the column. Preliminary observations were made to show the effect of the containers and the anticoagulant used. The influence on platelets when stored at 4 degrees C an...

Effects of drugs on platelet function.

Numerous drugs and chemicals affect the function of human blood platelets. The mechanism of action of some medications is partly understood. Aspirin is the most frequently involved drug. It appears to interfere with the platelet release reaction by acetylation of a platelet membrane protein which may be involved in the synthesis of prostaglandins. Other anti-inflammatory drugs, including indome...